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During the first two to four weeks, participants in trials have reported: Gastrointestinal effects: Nausea, vomiting, diarrhoea, constipation, and abdominal discomfort are among the most commonly reported side effects

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A separate model was fit for each outcome measure

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B12 supplementation is particularly relevant as GLP-1 agonists can affect absorption

This results in the transcriptional upregulation of pro-inflammatory cytokines (IL-1, TNF-, IL-6) [32], chemokines (CXCL8/IL-8, CCL2), antimicrobial peptides, and co-stimulatory molecules that enhance immune cell recruitment and activation [34]